华法林治疗的患者接受侵入性检查和手术期间的管理指南温医附二张荣.pptx

诚信 奉献 求精 创新Warfarin Therapy Management During Invasive Procedures and Surgery急诊外科 张 荣诚信 奉献 求精 创新诚信 奉献 求精 创新ScopeKey RecommendationsRisksManagement诚信 奉献 求精 创新ScopeKey RecommendationsRisksManagement诚信 奉献 求精 创新ScopeThis guideline provides recommendations for the management of warfarin therapy in adults aged 19 years requiring invasive procedures and surgery.Perioperative management of non-vitamin K antagonist oral anticoagulants can be found in BCGuidelines.ca Use of Use of NOACs in Non-Valvular Atrial FibrillationNOACs in Non-Valvular Atrial Fibrillation.Non-perioperative management of warfarin is covered in BCGuidelines.ca Warfarin Therapy ManagementWarfarin Therapy Management.诚信 奉献 求精 创新ScopeKey RecommendationsRisksManagement诚信 奉献 求精 创新Key Recommendations Warfarin discontinuation prior to invasive procedures is necessary for all interventional procedures except for minor skin procedures,routine dental work,cataract surgery,endoscopies without biopsy,and percutaneous venous access.For elective procedures,warfarin should be stopped for 5 to 6 days prior to the procedure to allow gradual normalization of the international normalized ratio(INR).For urgent procedures,use of prothrombin complex concentrate is highly effective in rapidly reversing warfarin anticoagulant activity and has a duration of action of 6 hours.The use of bridging heparin therapy is dependent on the risk of thrombosis.Discuss the risk of bleeding with the surgeon and anesthesiologist to determine optimal timing for resuming warfarin and bridging heparin therapy after surgery.诚信 奉献 求精 创新ScopeKey RecommendationsRisksManagement诚信 奉献 求精 创新RisksThe management of warfarin therapy in patients undergoing surgery or other invasive procedures involves a fine balance between the risk of hemorrhage if the procedure was performed while on warfarin,and the risk of thrombosis if warfarin was discontinued.The thrombotic risk in the perioperative period depends on pre-existing conditions,the time since the last episode of thrombosis,and the thrombotic effect of surgery.The risk of hemorrhage in the perioperative period depends on the patients age,associated medical conditions,type of procedure,approach,site,type of incision and closure,and the method of administration of anesthesia and analgesia.It is recommended that the anesthesiologist and the surgeon be consulted in determining the hemorrhagic risk诚信 奉献 求精 创新RisksPreoperative management of warfarin therapy consists of timely discontinuation of warfarin and replacement(known as“bridging”)with therapeutic low molecular weight heparin(LMWH)or unfractionated heparin if the risk of thrombosis is considered to be sufficiently high.Almost all patients will achieve an international normalized ration(INR)of 70 years)will require a longer period of warfarin withdrawal before surgery.Patients with a high risk of thromboembolism or stroke may benefit from bridging with heparin during the preoperative period,either as outpatients(LMWH subcutaneously)or inpatients(unfractionated heparin intravenously)by shortening the duration of subtherapeutic anticoagulation.诚信 奉献 求精 创新RisksPostoperative management of warfarin therapy consists of re-initiation of anticoagulation.Postoperative anticoagulation increases the rate of major bleeding.Typically,warfarin can resume the evening of or next day after the procedure because the anticoagulant activity is not established for several days.Restarting warfarin may be delayed in neurosurgical patients,those receiving epidural analgesia and in patients who are bleeding.For patients at high risk of thrombosis,LMWH by injection is given concurrently with warfarin and the overlap is maintained until a therapeutic INR has been reached.LMWH used postoperatively may allow earlier discharge of the patient compared with using unfractionated heparin.诚信 奉献 求精 创新RisksIf urgent or emergent procedures are to be undertaken in 4-5 days and warfarin reversal is required,it may be satisfactory to give 1-2 mg of vitamin K orally in order to expedite the reversal process.When reversal of anticoagulation is required within 6 hours,intravenous vitamin K and prothrombin complex concentrate(PCC)(e.g.,Octaplex,Beriplex)is highly effective and is recommended over frozen plasma infusion.诚信 奉献 求精 创新ScopeKey RecommendationsRisksManagement诚信 奉献 求精 创新Management诚信 奉献 求精 创新Management诚信 奉献 求精 创新Management诚信 奉献 求精 创新 Management of Perioperative Anticoagulation诚信 奉献 求精 创新Procedures associated with high and low risk for bleeding诚信 奉献 求精 创新Pre-existing conditions associated with higher and lower risk of thrombosis诚信 奉献 求精 创新Management of Perioperative Anticoagulation 诚信 奉献 求精 创新Management of Perioperative Anticoagulation 诚信 奉献 求精 创新诚信 奉献 求精 创新Management of Perioperative Anticoagulation 诚信 奉献 求精 创新Management of Perioperative Anticoagulation 诚信 奉献 求精 创新Management of Perioperative Anticoagulation 诚信 奉献 求精 创新诚信 奉献 求精 创新诚信 奉献 求精 创新Summary诚信 奉献 求精 创新1、rFVIIa not mentioned in this guideline2、Time-window of the surgery and invasive procedures 诚信 奉献 求精 创新 Thanks for listening！