医学免疫学英语试题.doc

ⅠChoose one which is the best answer in each question（40 × 1 point = 40 ）
1. Immunological unresponsiveness to self antigens is called: ( A)
窗体顶端
A  Tolerance B  Tolerogen C  Memory D  Acquired immunity
2. The signal transduction molecules associated with BCR are (B )
A. CD21 and CD81. B. Igαnd IgβCD79a,b C. IgD and IgM. D.ITAMs and ITIMs.
3. T cells are MHC-restricted in their ability to respond to antigen because (D )
A. all antigen must be processed and presented to activate lymphocytes.
B. during an infection, all cells in the body present antigen on MHC Class I.
C. MHC binds antigen more specifically than TCR does.
D. TCR must recognize both antigen and MHC molecules.
4. An antibody Fab contains ( A B)
A. complementarity determining regions. B. H and L chain variable regions. C. one antigen binding region. D. one H-L interchain disulfide bond.
5 Positive selection in the thymus is mediated by: ( A )
窗体顶端
A  Thymic epithelial cells. B  Macrophages. C  Dendritic cells. D  B-cells.
6. Type Ⅳ hypersentivity is often referred to as: ( B )
A. Immediate hypersensitivity B. Delayed hypersensitivity
C. Cytotoxic hypersensitivity D. Allergic hypersensitivity
7. Type Ⅱhypersentivity is often referred to as: ( C )
A. Immediate hypersensitivity B. Delayed hypersensitivity
C. Cytotoxic hypersensitivity D. Allergic hypersensitivity
8. Naive B cell expresses ( C )
A. IgA alone B.IgA and IgG C IgM +IgD D.IgE and Ig
9. T cell-derived cytokines ( D )
A. are antigen-specific products of T cell activation

B. are stored in the resting T cell and released on activation
C. are MHC-restricted in their effects
D. influence the class of antibodies produced by B cell
10. Neutrophils are attracted to an infected area by ( C )
A. IgM B. C1 C. C5a D. C8
11. Complement lyses cells by ( C )
A. enzymatic digestion of the cell membrane
B. activation of adenylate cyclase
C. insertion of complement proteins into the cell membrane
D. inhibition of elongation factor 2
12. CD8 is a marker of ( C)
A. B cells B. Helper - T cells C. cytotoxic T cell D. Mφ
13. MHC class Ⅱ molecules are found on (B )
A. Virtually all cells in the body B. B cells, DC and Mφ
C. Virtually all nucleated cells in the body D. Only on virally-infected cells.
14. All of following cytokines are secreted by Th2 cells except (B )
A. IL-4 B. IFN-γ C. IL-5 D. IL-6
15. Which of the following is NOT true of CD4+ and CD8+ cell markers? ( D )
A. These are both surface glycoproteins expressed on T-cells.
B. These serve to distinguish different types of T-cells, e.g., helper, suppressor and cytotoxic, from each other.
C. These are not found associated with immunoglobulins.
D. Both of the markers are present on ALL T-cells.
16.  Cells bearing MHC class I plus peptide are targets for specific: ( B )

A  B-cells. B  Cytotoxic T-cells. C  Th1 cells. D  Th2 cells.
17. Dendritic cells are characterized by: ( D )
A  the presence of major basic protein B  expression of CD3 C  expression of IgM molecules D  their interface between the innate and adaptive immune system
18. Which of the following uniquely distinguishes the T-cell receptor (TCR) from an antibody? ( A )
A. The TCR can bind an antigen fragment only in a trimolecular complex with either the class I or class II surface proteins of the major histocompatibility complex
B. The TCR can function as a cell surface antigen receptor
C. The TCR is composed of two different types of polypeptide chains
D. The TCR is capable of participating in a cytotoxic reaction.

19. A critical property of an antigen is ( A )
A. Its ability to stimulate an immune response
B. a unique topological feature called an paratope
C. not a unique topological feature called an antigenic determinant
D. the size of which is relatively small
20.Opsonization of bacteria occurs through coating bacteria just with: ( A )
窗体顶端
A  C3b B  C8 C  Membrane attack complex D  IgM
21. The following is characteristic of B- but not T-cells: ( D )
窗体顶端
A  Class I MHC. B  CD3. C  HIV virus receptor. D  Surface immunoglobulin.
22．Which of the following molecules is expressed on the surface of mature CD4+T cells? ( C )
A. B cell receptor B. CD1d C.CD3 D.CD8

23． The thymus is the site of initial differentiation for （ D ）
A. B cells B. Erythrocytes C. Hematopietic stem cells D. T cells
24. The membrane attack complex consists of: ( C )
A  OH B  C3b3b,Bb C  C5b,6,7,8,9 D  Properdin
25. Type Ⅰhypersentivity is often referred to as: (A )
A. Immediate hypersensitivity B. Delayed hypersensitivity
C. Cytotoxic hypersensitivity D. Immune complex hypersensitivity
26. Type Ⅲ hypersentivity is often referred to as: ( D)
A. Immediate hypersensitivity B. Delayed hypersensitivity
C. Cytotoxic hypersensitivity D. Immune complex hypersensitivity
27. The typeⅠhypersentivity is mediated by: ( D )
A. IgA B. IgD C. IgG D. IgE
28. The cytokine which is most involved in the class switch to IgE production is: ( D )
A.IL-1 B.IL-2 C.TGF beta D.IL-4
29. Which type hypersensitivity is related to the mechanism of acute Arthus reaction: ( C )
A. Type Ⅰhypersentivity B. Type Ⅱhypersentivity
C. Type Ⅲ hypersentivity D. Type Ⅳ hypersentivity
30. T-cell CD40L provides a costimulatory signal to B-cells by ligating: ( A )
窗体顶端
A  CD40 B  MHC class II C  CD28 D  CD19
31. Which immunoglobulin can be transported through the placenta? ( A )
A. IgG B. IgM C. Secretory IgA D. IgE
32. Which immunoglobulin is the most one in the blood? ( A )
A. IgG B. IgM C. Secretory IgA D. IgE
33. Which immunoglobulin can mediate the immediate hypersensitivity? (

D )
A. IgG B. IgM C. Secretory IgA D. IgE
34. Molecules directly involved in NK cell mediated killing include: ( B )
A  nitric oxide B  granzyme C  complement D  IFN-γ
35. Immune complexes consist of ( C )
A. antibody plus complement B. basophil plus complement
C. antigen plus antibody D. antigen plus complement
36.  The main costimulatory signal for activation of resting T-cells is provided by ligation of: ( A )
A  CD28 B  Surface Ig C  LFA-1 D  VLA-4
37.  The T-cell receptor antigen recognition signal is transduced by: ( E )
A  The TCR alpha chain. B  The TCR beta chain. D  CD2. E  CD3.
38.  The T-cell ligand binding B7 on a professional antigen-presenting cell is: A
A  CD28 B  CD2 C  LFA-1 D  ICAM-1
39.  Secondary antibody responses are better because: ( C)
A  They provide defense against unrelated antigens
B  The antibody can be made by both T and B cells
C  They are stronger and faster
D  They do not require T-cell help
40. Which cell type produces antibodies?: ( D )
A  Macrophages B  T-lymphocytes C  NK D  Plasma cells
II. Indicate whether each of the following statements is true or false. （10×2 points =20 ）
1. A hapten can stimulate antibody formation but cannot combine with antibody molecules. ( F)

2. Booster shots are required because repeated exposure to an antigen builds a stronger immune response. ( T)
3. The Igα/Igβ heterodimer and CD3 serve analogous functions in the B-cell receptor and T-cell receptor, respectively. ( T )
4. Antigen-presenting cells express both class I and class II MHC molecules on their membranes. ( T )
5. Babies can acquire IgE-mediated allergies by passive transfer of maternal antibody. ( F )
6. Both CTLs and NK cells release perforin after interacting with target cells. ( T )
7. Target cell lysis and destruction can be achieved by perforin released from antigen-specific cytotoxic T-cells ( T )
8. The immune response is mediated via the humoral and/or cellular arms of the immune system ( T )
9. Immediate type hypersensitivity is mediated by IgM. ( F )
10. All cytokine-binding receptors cintain two or three subunits. ( T )
Ⅲ Answer the following questions in brief （10×4points =40 ）
1. Name the three types of professional APCs, and give one example of nonprofessional APCs. B M DC endothelial cell
2. Summarize the four major functions of complement system ①lysis of cells, bacteria and viruses ②opsonization to enhance phagocytosis ③clearance of immune complexes ④stimulation of inflammation
3. List the classical Class I and Class II gene loci for humans
4. What dose " MHC restriction" mean?HLA-A,B,C HLA-DPDRDQ
5. To activate T cells, two molecules must be recognized on the antigen-presenting cells, what are they? Peptide-MHC

6. Compare the primary and secondary responses from the following points of view: (a) time for antibody to appear (b) quantity of antibody produced (c) class of antibody produced (d) duration of antibody production.
7. Compare Class I and Class II MHC proteins from the following points of view: (a) types of cells on which they are located (b) role in antigen recognition by CD4+ and CD8+ T cells.
8. Helper T cells can be divided into two subsets based on their lymphokine secretion profile. Explain.
9. What are the main functions of macrophages?
10. Please draw a schematic diagram of a typical IgG molecule and label each part of the chains.

（注：专业文档是经验性极强的领域，无法思考和涵盖全面，素材和资料部分来自网络，供参考。可复制、编制，期待你的好评与关注）